Thermo Fisher Scientific offers an array of imaging reagents and kits to detect cells undergoing apoptosis. Select from a wide variety of caspase activity assays, DNA fragmentation and TUNEL assays, annexin V staining reagents and mitochondrial assays.
Many different approaches are used in the study of programmed cell death, or apoptosis. Cell death cascades are complex and dynamic, underscoring the importance of a multi-parametric approach for accurate assessment. Understanding the mechanisms of cell death and survival can represent a critical aspect of toxicological profiling and drug discovery. See our range of imaging assays to detect apoptotic cells undergoing processes ranging from caspase activation to phosphatidylserine translocation.
Annexin V staining is used to detect a hallmark of apoptosis, translocation of phosphatidylserine to the outer leaflet of the plasma membrane.
Activation of caspase enzymes is a distinctive feature of apoptosis.
DNA fragmentation and chromatin condensation are observed changes during apoptosis.
Disruption of mitochondria function is a distinguishing feature of apoptosis.