RNAi is a specific, potent, and highly successful approach for loss-of-function studies in virtually all eukaryotic organisms. At Thermo Fisher Scientific, we have developed two types of small RNA molecules that function in RNAi: short interfering RNA (siRNA) molecules and microRNAs (miRNA). Thermo Fisher Scientific offers Invitrogen™ products for RNAi analysis in vitro and in vivo, including libraries for high-throughput applications. Your choice of tool depends on your model system, the length of time you require knockdown, and other experimental parameters.

siRNA

Effectively knock down gene expression using our proprietary Silencer Select, Stealth RNAi, and Silencer siRNAs

miRNA

Analyze miRNA function with Invitrogen mirVana miRNA mimics and inhibitors

RNAi controls

Find a complete solution for successful in vivo RNAi experiments including the highest nuclease stability Invitrogen™ Ambion™ In Vivo siRNA

RNAi Transfection

Determine the best approach for delivering RNAi to your cells using either lipid-mediated transfection (Invitrogen Lipofectamine reagents) or the Invitrogen Neon Transfection System

siRNA libraries

Increase discovery with the widest selection of predefined and custom RNAi libraries available

In Vivo siRNA

Find a complete solution for successful in vivo RNAi experiments including the highest nuclease stability Ambion In Vivo siRNA

Vector-Based RNAi

Reagents & kits to achieve transient or stable target knockdown in hard-to-transfect cells including Invitrogen BLOCK-iT system products